Thru-reflect-line calibration for substrate integrated waveguide devices with tapered microstrip transitions

One of the main problems when exciting or measuring substrate integrated waveguide (SIW) devices lies in the need of a good interconnection with planar structures. In this reported work, the negative effects produced by the connectors and the tapered microstrip-to-SIW transitions are de-embedded from the measurements of the SIW structure by a thru-reflect-line calibration with an adequate and cheap SIW calibration kit.Díaz Caballero, E.; Belenguer Martínez, Á.; Esteban González, H.; Boria Esbert, VE. (2013). Thru-reflect-line calibration for substrate integrated waveguide devices with tapered microstrip transitions. Electronics Letters. 49(2):132-133. doi:10.1049/el.2012.3027S132133492Deslandes, D., & Wu, K. (2001). Integrated microstrip and rectangular waveguide in planar form. IEEE Microwave and Wireless Components Letters, 11(2), 68-70. doi:10.1109/7260.914305Henry, M., Free, C. E., Izqueirdo, B. S., Batchelor, J., & Young, P. (2009). Millimeter Wave Substrate Integrated Waveguide Antennas: Design and Fabrication Analysis. IEEE Transactions on Advanced Packaging, 32(1), 93-100. doi:10.1109/tadvp.2008.2011284Chen, X.-P., Wu, K., & Li, Z.-L. (2007). Dual-Band and Triple-Band Substrate Integrated Waveguide Filters With Chebyshev and Quasi-Elliptic Responses. IEEE Transactions on Microwave Theory and Techniques, 55(12), 2569-2578. doi:10.1109/tmtt.2007.909603Deslandes, D., & Ke Wu. (2005). Analysis and design of current probe transition from grounded coplanar to substrate integrated rectangular waveguides. IEEE Transactions on Microwave Theory and Techniques, 53(8), 2487-2494. doi:10.1109/tmtt.2005.852778Engen, G. F., & Hoer, C. A. (1979). Thru-Reflect-Line: An Improved Technique for Calibrating the Dual Six-Port Automatic Network Analyzer. IEEE Transactions on Microwave Theory and Techniques, 27(12), 987-993. doi:10.1109/tmtt.1979.1129778Chih-Jung Chen, & Tah-Hsiung Chu. (2009). Measurement of Noncoaxial Multiport Devices Up to the Intrinsic Ports. IEEE Transactions on Microwave Theory and Techniques, 57(5), 1230-1236. doi:10.1109/tmtt.2009.201735

QSAR Classification Models for Predicting the Activity of Inhibitors of Beta-Secretase (BACE1) Associated with Alzheimer’s Disease

Alzheimer’s disease is one of the most common neurodegenerative disorders in elder population. The β-site amyloid cleavage enzyme 1 (BACE1) is the major constituent of amyloid plaques and plays a central role in this brain pathogenesis, thus it constitutes an auspicious pharmacological target for its treatment. In this paper, a QSAR model for identification of potential inhibitors of BACE1 protein is designed by using classification methods. For building this model, a database with 215 molecules collected from different sources has been assembled. This dataset contains diverse compounds with different scaffolds and physical-chemical properties, covering a wide chemical space in the drug-like range. The most distinctive aspect of the applied QSAR strategy is the combination of hybridization with backward elimination of models, which contributes to improve the quality of the final QSAR model. Another relevant step is the visual analysis of the molecular descriptors that allows guaranteeing the absence of information redundancy in the model. The QSAR model performances have been assessed by traditional metrics, and the final proposed model has low cardinality, and reaches a high percentage of chemical compounds correctly classified.Fil: Ponzoni, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias e Ingeniería de la Computación. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación. Instituto de Ciencias e Ingeniería de la Computación; Argentina. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación. Instituto de Ciencias e Ingeniería de la Computación; ArgentinaFil: Sebastián Pérez, Víctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias e Ingeniería de la Computación. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación. Instituto de Ciencias e Ingeniería de la Computación; Argentina. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; EspañaFil: Martínez, María J.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias e Ingeniería de la Computación. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación. Instituto de Ciencias e Ingeniería de la Computación; Argentina. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación. Instituto de Ciencias e Ingeniería de la Computación; ArgentinaFil: Roca, Carlos. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; EspañaFil: De la Cruz Pérez, Carlos. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; EspañaFil: Cravero, Fiorella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Vazquez, Gustavo Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Católica del Uruguay; UruguayFil: Páez, Juan A.. Consejo Superior de Investigaciones Científicas. Instituto de Química Médica; EspañaFil: Diaz, Monica Fatima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; ArgentinaFil: Campillo Martín, Nuria Eugenia. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; Españ

Risk factors for premature aging of placenta: comparative study of perinatal outcomes between grannum grade III placentas and grannum grade I-II placentas

Introduction: The placenta aging has been related with intrauterine fetal growth, low maternal age, Caucasian, multiparity, hypertensive states and smoking habit. Grannum P. classification is the most used for its assessment. The association between grade III placenta (G3P) and ex-smoking or smokeexposed pregnants has not been studied Main outcome: To asses if smoking, being an ex-smoker or a passive-smoker is a risk factor for developing grade III placenta, as well as if there is a smoking-free period of time to avoid the effect of smoking over placenta Material and methods: A retrospective case-control study of single pregnancies followed-up at the Obstetric Ultrasound Unit between January 2013 and January 2014. Placental grading according to Grannum classification was stablished through abdominal approach between 34-36 weeks of gestation and two groups were established: grade III placenta and grade I-II placenta (G1-2P) Maternal and paternal characteristics, type of delivery and perinatal outcomes were collected Results: Baseline characteristics were similar between the two groups. In G3P the incidence of hypertensive disease of pregnancy was higher(p=0,0107). The percentage was similar for premature birth, 1st and 5th minute Apgar, type of delivery and cesarean due to risk of loss of fetal wellbeing. A lower neonatal weight was found in G3P, at the same median days at delivery, with a mean difference of 148,156(p=0,008313. Regarding weight percentile, it was found a p35 in G3P and a p47,5 in G1- 2P(p=0,08235) 15% of the total pregnant were smokers. In G3P group it was found a higher frequency of smokers and ex-smokers since 1st trimester of pregnancy (p=0.0001), as well as pregnant non-smokers with an smoking partner(p=0,0001). There was an strong evidence for association between pregnant smokers and smoking partners(p=0,0001). No difference was found regarding to neonatal weight comparing smokers, ex-smokers and ex-smokers since 1st trimester of pregnancy. The length of pregnancy was lower between G3P pregnant smokers compared to G1-2P pregnant smokers, with a mean difference of 8 days (p=0,00091) Conclusions: There is a strong evidence for association between smoking during pregnancy, quitting smoking at the beginning of the pregnancy or being a passive smoker with development of G3P Some pregnant smokers don`t develop premature aging of placenta, it could be due to either other parameters or a later aging (data were collected between 34-36 weeks). The association between quitting smoking at the beginning of the pregnancy and not having a smoking partner reduces the risk of developing G3

New Models for Wolf-Rayet and O Star Populations in Young Starbursts

Using the latest stellar evolution models, theoretical stellar spectra, and a compilation of observed emission line strengths from Wolf-Rayet (WR) stars, we construct evolutionary synthesis models for young starbursts. We explicitly distinguish between the various WR subtypes (WN, WC, WO), and we treat O and Of stars separately. We provide detailed predictions of UV and optical emission line strengths for both the WR stellar lines and the major nebular hydrogen and helium emission lines, as a function of several input parameters related to the starburst episode. We also derive the theoretical frequency of WR-rich starbursts. We then discuss: nebular HeII 4686 emission, the contribution of WR stars to broad Balmer line emission, techniques used to derive the WR and O star content from integrated spectra, and explore the implications of the formation of WR stars through mass transfer in close binary systems in instantaneous bursts. The observational features predicted by our models allow a detailed quantitative determination of the massive star population in a starburst region (particularly in so-called "WR galaxies") from its integrated spectrum and provide a means of deriving the burst properties (e.g., duration, age) and the parameters of the initial mass function of young starbursts. (Abridged abstract)Comment: Accepted by ApJ Supplements. LaTeX using aasmp4, psfigs macros. 49 pages including 23 figures. Paper (full, or text/figures separated) and detailed model results available at http://www.stsci.edu/ftp/science/starburst/sv97.htm

Improving Latin American soil information database for digital soil mapping enhances its usability and scalability

Spatial soil databases can help model complex phenomena in which soils are decisive, for example, evaluating agricultural potential or estimating carbon storage capacity. The Soil Information System for Latin America and the Caribbean, SISLAC, is a regional initiative promoted by the FAO's South American Soil Partnership to contribute to the sustainable management of soil. SISLAC includes data coming from 49,084 soil profiles distributed unevenly across the continent, making it the region's largest soil database. However, some problems hinder its usages, such as the quality of the data and its high dimensionality. The objective of this research is twofold. First, to evaluate the quality of SISLAC and its data values and generate a new, improved version that meets the minimum quality requirements to be used by different interests or practical applications. Second, to demonstrate the potential of improved soil profile databases to generate more accurate information on soil properties, by conducting a case study to estimate the spatial variability of the percentage of soil organic carbon using 192 profiles in a 1473 km2 region located in the department of Valle del Cauca, Colombia. The findings show that 15 percent of the existing soil profiles had an inaccurate description of the diagnostic horizons. Further correction of an 4.5 additional percent of existing inconsistencies improved overall data quality. The improved database consists of 41,691 profiles and is available for public use at ttps://doi.org/10.5281/zenodo.6540710 (Díaz-Guadarrama, S. & Guevara, M., 2022). The updated profiles were segmented using algorithms for quantitative pedology to estimate the spatial variability. We generated segments one centimeter thick along with each soil profile data, then the values of these segments were adjusted using a spline-type function to enhance vertical continuity and reliability. Vertical variability was estimated up to 150 cm in-depth, while ordinary kriging predicts horizontal variability at three depth intervals, 0 to 5, 5 to 15, and 15 to 30 cm, at 250 m-spatial resolution, following the standards of the GlobalSoilMap project. Finally, the leave-one-out cross validation provides information for evaluating the kriging model performance, obtaining values for the RMSE index between 1.77% and 1.79% and the R2 index greater than 0.5. The results show the usability of SISLAC database to generate spatial information on soil properties and suggest further efforts to collect a more significant amount of data to guide sustainable soil management.Fil: Diaz Guadamarra, Sergio. Universidad Nacional de Colombia. Facultad de Ciencias Agrarias. Departamento de Agronomía; ColombiaFil: Lizarazo, Iván. Universidad Nacional de Colombia. Facultad de Ciencias Agrarias. Departamento de Agronomía; ColombiaFil: Guevara, Mario. Universidad Nacional Autónoma de México. Campus Juriquilla. Centro de Geociencias; MéxicoFil: Guevara, Mario. Universidad Nacional Autónoma de México.Campus Juriquilla. Centro de Geociencias; México. United States Department of Agriculture. Soil Salinity National Laboratory, Estados UnidosFil: Angelini, Marcos Esteban. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Suelos; Argentina. Wageningen University. Soil Geography and Landscape Group; Países Bajos. International Soil Reference and Information Centre. World Soil Information; Países BajosFil: Araujo Carrillo, Gustavo A. Corporación Colombiana de Investigación Agropecuaria AGROSAVIA; ColombiaFil: Argeñal, Jainer. Universidad Nacional Autónoma de Honduras. Facultad de Ciencias; Honduras.Fil: Armas, Daphne. Universidad de Almería. Departamento de Agronomía, Edif. CITEIIB, España.Fil: Balsa, Rafael A. Ministerio de Desarrollo Agrario y Riego. Dirección General de Asuntos Ambientales Agrarios, Perú.Fil: Bolivar, Adriana. Instituto Geográfico Agustín Codazzi. Subdirección Agrología; ColombiaFil: Bustamante, Nelson. Servicio Agrícola y Ganadero; Chile.Fil: Dart, Ricardo O. Embrapa Solos; BrasilFil: Dell Acqua, Martín. Ministerio de Ganadería, Agricultura y Pesca. Dirección General de Recursos Naturales; UruguayFil: Lencina, Arnulfo. Universidad Nacional de Asunción. Facultad de Ciencias Agrarias; ParaguayFil: Figueredo, Hernán. Sociedad Boliviana de la Ciencia del Suelo; Bolivia.Fil: Fontes, Fernando. Ministerio de Ganadería, Agricultura y Pesca. Dirección General de Recursos Naturales; UruguayFil: Gutierrez Diaz, Joan S. Aarhus University. Faculty of Science and Technology,.Department of Agroecology; DinamarcaFil: Jiménez, Wilmer. Ministerio de Agricultura y Ganadería; Ecuador.Fil: Rodriguez, Dario Martin. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Suelos; ArgentinaFil: Schulz, Guillermo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Suelos; ArgentinaFil: Tenti Vuegen, Leonardo Mauricio. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Suelos; Argentin

The cefazolin inoculum effect is associated with increased mortality in methicillin-susceptible staphylococcus aureus bacteremia

Background. Recent studies have favored the use of cefazolin over nafcillin for the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. The clinical influence of the cefazolin inoculum effect (CzIE) in the effectiveness of cephalosporins for severe MSSA infections has not been evaluated. Methods. We prospectively included patients from 3 Argentinian hospitals with S. aureus bacteremia. Cefazolin minimum inhibitory concentrations (MICs) were determined at standard (105 colony-forming units [CFU]/mL) and high (107 CFU/mL) inoculum. The CzIE was defined as an increase of MIC to ≥16 µg/mL when tested at high inoculum. Whole-genome sequencing was performed in all isolates. Results. A total of 77 patients, contributing 89 MSSA isolates, were included in the study; 42 patients (54.5%) had isolates with the CzIE. In univariate analysis, patients with MSSA exhibiting the CzIE had increased 30-day mortality (P = .034) and were more likely to have catheter-associated or unknown source of bacteremia (P = .033) compared with patients infected with MSSA isolates without the CzIE. No statistically significant difference between the groups was observed in age, clinical illness severity, place of acquisition (community vs hospital), or presence of endocarditis. The CzIE remained associated with increased 30-day mortality in multivariate analysis (risk ratio, 2.65; 95% confidence interval, 1.10-6.42; P = .03). MSSA genomes displayed a high degree of heterogeneity, and the CzIE was not associated with a specific lineage. Conclusions. In patients with MSSA bacteremia where cephalosporins are used as firstline therapy, the CzIE was associated with increased 30-day mortality. Clinicians should be cautious when using cefazolin as firstline therapy for these infections.Fil: Goss, William Miller. University of Texas; Estados UnidosFil: Seas, Carlos. Universidad Peruana Cayetano Heredia; PerúFil: Carvajal, Lina P.. Universidad El Bosque; ColombiaFil: Diaz, Lorena. Universidad El Bosque; Colombia. UTHealth McGovern Medical School; Estados UnidosFil: Echeverri, Aura M.. Universidad El Bosque; ColombiaFil: Ferro, Carolina. Universidad El Bosque; ColombiaFil: Rios, Rafael. Universidad El Bosque; ColombiaFil: Porras, Paola. Universidad El Bosque; ColombiaFil: Luna, Carlos. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Gotuzzo, Eduardo. Universidad Peruana Cayetano Heredia; PerúFil: Munita, Jose M.. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; ChileFil: Nannini, Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Carcamo, Cesar. Universidad Peruana Cayetano Heredia; PerúFil: Reyes, Jinnethe. Universidad El Bosque; ColombiaFil: Arias, Cesar A.. University of Texas; Estados Unido

Optical Recombination Lines of Heavy-elements in Giant Extragalactic HII Regions

We present high resolution observations of the giant extragalactic H II regions NGC 604, NGC 2363, NGC 5461 and NGC 5471, based on observations taken with the ISIS spectrograph on the William Herschel Telescope. We have detected -by the first time- C II and O II recombination lines in these objects. We find that recombination lines give larger C^{++} and O^{++} abundances than collisionallly excited lines, suggesting that temperature variations can be present in the objects. We detect [Fe IV] lines in NGC 2363 and NGC 5471, the most confident detection of optical lines of this kind in H II regions. Considering the temperature structure we derive their H, He, C, N, O, Ne, S, Ar, and Fe abundances. From the recombination lines of NGC 5461 and NGC 5471 we determine the presence of C/H and O/H gradients in M101. We calculate the Delta Y/Delta O and Delta Y/Delta Z values considering the presence of temperature variations and under the assumption of constant temperature. We obtain a better agreement with models of galactic chemical evolution by considering the presence of temperature variations than by assuming that the temperature is constant in these nebulae.Comment: 42 pages, 5 figures. To be published in Ap